Genhouse Bio Licensed SHP2 Inhibitor to HUYABIO International in Ex-China Territories for a Total Value of $282M


On September 9th 2020, Genhouse Bio, a biotech company focusing on development of next-generation anti-cancer therapeutics, announced today that it has entered exclusive license agreement with HUYABIO International for ex-China rights of its SHP2 inhibitor, GH21. The total deal value, including upfront and milestone payments, is $282M plus royalties of ex-China sales.


“SHP2 is becoming a validated target with broad therapeutic potential. SHP2 inhibitors are expected to benefit patients with multiple types of tumors,” said Kuifeng Wang, Ph.D., Founder and CEO of Genhouse, “Preclinical study has demonstrated that GH21 has high bioavailability, good safety profile, significant anti-tumor efficacy in both in vitro and in vivo models. GH21 is about to enter clinical development globally. We believe the partnership with HUYABIO will help to accelerate its global development and commercialization. ”


“We are glad to sign this licensing agreement with Genhouse to add one more exciting asset to our pipeline,” said Mireille Gillings, Ph.D., CEO and Executive President of HUYABIO, “There is still enormous unmet medical need for better and safer cancer treatments. The preclinical data of GH21 exceeds our expectation—GH21 is a very promising drug candidates with broad potential to treat multiple tumor types.”


About SHP2

SHP2, also known as Tyrosine-protein Phosphatase Non-receptor Type 11 (PTPN11), is the first oncogenic tyrosine-protein phosphatase discovered in history. Recently, SHP2 has drawn broad attention. On one hand, it is at the downstream of most RTK pathways, transducing cell proliferative and survival signals for RAS-MAPK/PI3K-mTOR pathway. On the other hand, SHP2 is also at the downstream of multiple immune checkpoints, such as PD-1 and BTLA, transducing immune escape signal in cancer cells, which gives SHP2 broad combo potential with immune checkpoint inhibitors. Therefore, SHP2 inhibitors are believed to have dual effects in both the RTK pathways and immune oncology.


About GH21

GH21 is a SHP2 allosteric inhibitor developed independently by Genhouse with global IP rights. GH21 has very high selectivity and is effective against multiple SHP2 point mutants. Both in vitro and in vivo studies have shown that GH21 does not affect any other tyrosine-protein phosphatases besides SHP2, thus has very low off-target risk. Moreover, GH21 has very good PK and safety profile, and a broad therapeutic window. Therefore, GH21 is a very promising small molecule drug candidate.


About Genhouse

Genhouse Bio is a clinical-stage biotech company focusing on the development of global next-generation anti-cancer therapeutics, headquartered in the Suzhou Industry Park . The senior management team of Genhouse has multiple years of experience in new drug development, clinical research, and corporate management. Genhouse has a clear focus on original innovation and overcoming those “undruggable” targets.

Genhouse has established intergrated in-house drug development platforms. With these platforms, Genhouse has started to build a highly innovative anti-cancer pipeline and out-licensed the ex-China rights of its SHP2 inhibitor GH21 to HUYABIO , an international biotech company. Genhouse will continue to advance more innovative pipeline programs into global development.


About HUYABIO International

HUYABIO is the leader in accelerating the global development of novel biopharmaceutical product opportunities originating in China enabling faster, more cost-effective and lower-risk drug development in international markets. Through extensive collaboration with biopharmaceutical, academic and commercial organizations, it has built the largest China-sourced compound portfolio covering all therapeutic areas. With offices in the US, Japan, South Korea, Canada, Ireland and eight strategic locations across China, the Company has become a partner of choice to accelerate product development and maximize value globally. For more information, please visit

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Effective and Last Updated: April 15th 2021